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Selective inhibitors of nuclear export (SINE)– a novel class of anti-cancer agents

Dysregulation of the nucleo-cytoplasmic transport of proteins plays an important role in carcinogenesis. The nuclear export of proteins depends on the activity of transport proteins, exportins. Exportins belong to the karyopherin β superfamily. Exportin-1 (XPO1), also known as chromosomal region mai...

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Bibliographic Details
Main Authors: Parikh, Kaushal, Cang, Shundong, Sekhri, Arunabh, Liu, Delong
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200201/
https://ncbi.nlm.nih.gov/pubmed/25316614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-014-0078-0
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