MicroRNA-188 suppresses G(1)/S transition by targeting multiple cyclin/CDK complexes

BACKGROUND: Accelerated cell cycle progression is the common feature of most cancers. MiRNAs can act as oncogenes or tumor suppressors by directly modulating cell cycle machinery. It has been shown that miR-188 is upregulated in UVB-irradiated mouse skin and human nasopharyngeal carcinoma CNE cells...

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Detalhes bibliográficos
Main Authors: Wu, Jiangbin, Lv, Qing, He, Jie, Zhang, Haoxiang, Mei, Xueshuang, Cui, Kai, Huang, Nunu, Xie, Weidong, Xu, Naihan, Zhang, Yaou
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200121/
https://ncbi.nlm.nih.gov/pubmed/25304455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-014-0066-6
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