MicroRNA-188 suppresses G(1)/S transition by targeting multiple cyclin/CDK complexes

BACKGROUND: Accelerated cell cycle progression is the common feature of most cancers. MiRNAs can act as oncogenes or tumor suppressors by directly modulating cell cycle machinery. It has been shown that miR-188 is upregulated in UVB-irradiated mouse skin and human nasopharyngeal carcinoma CNE cells...

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Bibliographic Details
Main Authors:	Wu, Jiangbin, Lv, Qing, He, Jie, Zhang, Haoxiang, Mei, Xueshuang, Cui, Kai, Huang, Nunu, Xie, Weidong, Xu, Naihan, Zhang, Yaou
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2014
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4200121/ https://ncbi.nlm.nih.gov/pubmed/25304455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-014-0066-6
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MicroRNA-188 suppresses G(1)/S transition by targeting multiple cyclin/CDK complexes

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