MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis

Damage to mitochondria often results in the activation of both mitophagy and mitochondrial apoptosis. The elimination of dysfunctional mitochondria is necessary for mitochondrial quality maintenance and efficient energy supply. Here we report that miR-181a is a novel inhibitor of mitophagy. miR-181a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cheng, Min, Liu, Lei, Lao, Yuanzhi, Liao, Weijie, Liao, Meijian, Luo, Xuan, Wu, Jiangbin, Xie, Weidong, Zhang, Yaou, Xu, Naihan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173134/
https://ncbi.nlm.nih.gov/pubmed/27281615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9786
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