Nuclear Expression of the Deubiquitinase CYLD Is Associated with Improved Survival in Human Hepatocellular Carcinoma

BACKGROUND & AIMS: The deubiquitinase CYLD removes (K-63)-linked polyubiquitin chains from proteins involved in NF-κB, Wnt/ß-catenin and Bcl-3 signaling. Reduced CYLD expression has been reported in different tumor entities, including hepatocellular carcinoma (HCC). Furthermore, loss of CYLD has...

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Autori principali: Welte, Stefan, Urbanik, Toni, Elßner, Christin, Kautz, Nicole, Koehler, Bruno Christian, Waldburger, Nina, Bermejo, Justo Lorenzo, Pinna, Federico, Weiss, Karl-Heinz, Schemmer, Peter, Jaeger, Dirk, Longerich, Thomas, Breuhahn, Kai, Schulze-Bergkamen, Henning
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199737/
https://ncbi.nlm.nih.gov/pubmed/25329885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110591
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