Nuclear expression of the deubiquitinase CYLD is associated with improved survival in human hepatocellular carcinoma.

The deubiquitinase CYLD removes (K-63)-linked polyubiquitin chains from proteins involved in NF-κB, Wnt/ß-catenin and Bcl-3 signaling. Reduced CYLD expression has been reported in different tumor entities, including hepatocellular carcinoma (HCC). Furthermore, loss of CYLD has been shown to contribu...

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Detalhes bibliográficos
Main Authors: Stefan Welte, Toni Urbanik, Christin Elßner, Nicole Kautz, Bruno Christian Koehler, Nina Waldburger, Justo Lorenzo Bermejo, Federico Pinna, Karl-Heinz Weiss, Peter Schemmer, Dirk Jaeger, Thomas Longerich, Kai Breuhahn, Henning Schulze-Bergkamen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2014-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC4199737?pdf=render
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