C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency

Mutation is associated with developmental and hereditary disorders, aging, and cancer. While we understand some mutational processes operative in human disease, most remain mysterious. We used Caenorhabditis elegans whole-genome sequencing to model mutational signatures, analyzing 183 worm populatio...

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Detalhes bibliográficos
Main Authors: Meier, Bettina, Cooke, Susanna L., Weiss, Joerg, Bailly, Aymeric P., Alexandrov, Ludmil B., Marshall, John, Raine, Keiran, Maddison, Mark, Anderson, Elizabeth, Stratton, Michael R., Gartner, Anton, Campbell, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199376/
https://ncbi.nlm.nih.gov/pubmed/25030888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.175547.114
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