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The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity

Histone variant H3.3 is deposited in chromatin at active sites, telomeres, and pericentric heterochromatin by distinct chaperones, but the mechanisms of regulation and coordination of chaperone-mediated H3.3 loading remain largely unknown. We show here that the chromatin-associated oncoprotein DEK r...

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Autors principals: Ivanauskiene, Kristina, Delbarre, Erwan, McGhie, James D., Küntziger, Thomas, Wong, Lee H., Collas, Philippe
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199371/
https://ncbi.nlm.nih.gov/pubmed/25049225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.173831.114
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