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Ptch2 mediates the Shh response in Ptch1(−/−) cells

The Hedgehog (Hh) signaling response is regulated by the interaction of three key components that include the sonic hedgehog (Shh) ligand, its receptor patched 1 (Ptch1) and the pathway activator smoothened (Smo). Under the prevailing model of Shh pathway activation, the binding of Shh to Ptch1 (the...

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Bibliografski detalji
Glavni autori: Alfaro, Astrid C., Roberts, Brock, Kwong, Lina, Bijlsma, Maarten F., Roelink, Henk
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199129/
https://ncbi.nlm.nih.gov/pubmed/25085974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.110056
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