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Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein
Aberrant polypeptides in the endoplasmic reticulum (ER) are retro-translocated to the cytoplasm and degraded by the 26S proteasome via ER-associated degradation (ERAD). To begin to resolve the requirements for the retro-translocation and degradation steps during ERAD, a cell-free assay was used to i...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419910/ https://ncbi.nlm.nih.gov/pubmed/15152188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600232 |
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