Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein

Aberrant polypeptides in the endoplasmic reticulum (ER) are retro-translocated to the cytoplasm and degraded by the 26S proteasome via ER-associated degradation (ERAD). To begin to resolve the requirements for the retro-translocation and degradation steps during ERAD, a cell-free assay was used to i...

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Detalhes bibliográficos
Main Authors: Lee, Robert J, Liu, Chang-wei, Harty, Carol, McCracken, Ardythe A, Latterich, Martin, Römisch, Karin, DeMartino, George N, Thomas, Philip J, Brodsky, Jeffrey L
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC419910/
https://ncbi.nlm.nih.gov/pubmed/15152188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600232
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