Caveolin-1 Modulates Cardiac Gap Junction Homeostasis and Arrhythmogenecity by Regulating cSrc Tyrosine Kinase

BACKGROUND: Genome wide association studies (GWAS) have revealed significant association of caveolin-1 (Cav1) gene variants with increased risk of cardiac arrhythmias. Nevertheless, the mechanism for this linkage is unclear. METHODS AND RESULTS: Using adult Cav1(−/−) mice, we revealed a marked reduc...

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Autori principali: Yang, Kai-Chien, Rutledge, Cody A., Mao, Mao, Bakhshi, Farnaz R., Xie, An, Liu, Hong, Bonini, Marcelo G., Patel, Hemal H., Minshall, Richard D., Dudley, Samuel C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198950/
https://ncbi.nlm.nih.gov/pubmed/25017399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.113.001394
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