Deletion of the Mouse P450c17 Gene Causes Early Embryonic Lethality

Dehydroepiandrosterone (DHEA), a 19-carbon precursor of sex steroids, is abundantly produced in the human but not the mouse adrenal. However, mice produce DHEA and DHEA-sulfate (DHEAS) in the fetal brain. DHEA stimulates axonal growth from specific populations of mouse neocortical neurons in vitro,...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Bair, Susanna R., Mellon, Synthia H.
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 2004
Sujets:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419874/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15169901/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.12.5383-5390.2004
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