BET-bromodomain inhibition of MYC-amplified medulloblastoma

PURPOSE: MYC-amplified medulloblastomas are highly lethal tumors. BET bromodomain inhibition has recently been shown to suppress MYC-associated transcriptional activity in other cancers. The compound JQ1 inhibits BET bromodomain-containing proteins, including BRD4. Here we investigate BET bromodomai...

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Hauptverfasser: Bandopadhayay, Pratiti, Bergthold, Guillaume, Nguyen, Brian, Schubert, Simone, Gholamin, Sharareh, Tang, Yujie, Bolin, Sara, Schumacher, Steven E, Zeid, Rhamy, Masoud, Sabran, Yu, Furong, Vue, Nujsaubnusi, Gibson, William J, Paolella, Brenton R, Mitra, Siddharta, Cheshier, Samuel, Qi, Jun, Liu, Kun-Wei, Wechsler-Reya, Robert, Weiss, William A, Swartling, Fredrik J, Kieran, Mark W, Bradner, James E, Beroukhim, Rameen, Cho, Yoon-Jae
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198154/
https://ncbi.nlm.nih.gov/pubmed/24297863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2281
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