PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat

[Image: see text] Histone deacetylase (HDAC) enzymes have been demonstrated as critical components in maintaining chromatin homeostasis, CNS development, and normal brain function. Evidence in mouse models links HDAC expression to learning, memory, and mood-related behaviors; small molecule HDAC inh...

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Bibliografiske detaljer
Main Authors: Schroeder, F. A., Wang, C., Van de Bittner, G. C., Neelamegam, R., Takakura, W. R., Karunakaran, A., Wey, H. Y., Reis, S. A., Gale, J., Zhang, Y. L., Holson, E. B., Haggarty, S. J., Hooker, J. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198064/
https://ncbi.nlm.nih.gov/pubmed/25188794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500162j
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