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Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance

Despite major efforts, our knowledge about many brain diseases remains remarkably limited. Epigenetic dysregulation has been one of the few leads toward identifying the causes and potential treatments of psychiatric disease over the past decade. A new positron emission tomography radiotracer, [(11)C...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Strebl, Martin G., Wang, Changning, Schroeder, Frederick A., Placzek, Michael S., Wey, Hsiao-Ying, Van de Bittner, Genevieve C., Neelamegam, Ramesh, Hooker, Jacob M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784429/
https://ncbi.nlm.nih.gov/pubmed/26675505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00297
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