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PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation

Autophagosome formation is promoted by the PI3 kinase complex and negatively regulated by myotubularin phosphatases, indicating that regulation of local phosphatidylinositol 3-phosphate (PtdIns3P) levels is important for this early phase of autophagy. Here, we show that the Caenorhabditis elegans my...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wu, Yanwei, Cheng, Shiya, Zhao, Hongyu, Zou, Wei, Yoshina, Sawako, Mitani, Shohei, Zhang, Hong, Wang, Xiaochen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198041/
https://ncbi.nlm.nih.gov/pubmed/25124690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438618
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