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Loss of C. elegans GON-1, an ADAMTS9 Homolog, Decreases Secretion Resulting in Altered Lifespan and Dauer Formation

ADAMTS9 is a metalloprotease that cleaves components of the extracellular matrix and is also implicated in transport from the endoplasmic reticulum (ER) to the Golgi. It has been reported that an ADAMTS9 gene variant is associated with type 2 diabetes. The underlying pathology of type 2 diabetes is...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Yoshina, Sawako, Mitani, Shohei
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517882/
https://ncbi.nlm.nih.gov/pubmed/26218657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133966
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