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Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice
ProBMP4 is generated as a latent precursor that is sequentially cleaved at two sites within the prodomain to generate an active ligand. An initial cleavage occurs adjacent to the ligand domain, which generates a non-covalently associated prodomain/ligand complex that is subsequently dissociated by c...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Company of Biologists
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4197676/ https://ncbi.nlm.nih.gov/pubmed/24993941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.110130 |
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