The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo

Bone morphogenetic proteins 4 and 7 (BMP4 and BMP7) are morphogens that signal as either homodimers or heterodimers to regulate embryonic development and adult homeostasis. BMP4/7 heterodimers exhibit markedly higher signaling activity than either homodimer, but the mechanism underlying the enhanced...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Neugebauer, Judith M., Kwon, Sunjong, Kim, Hyung-Seok, Donley, Nathan, Tilak, Anup, Sopory, Shailaja, Christian, Jan L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426409/
https://ncbi.nlm.nih.gov/pubmed/25902523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501449112
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