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Regulation of Dpp activity by tissue-specific cleavage of an upstream site within the prodomain
BMP4 is synthesized as an inactive precursor that is cleaved at two sites during maturation: initially at a site (S1) adjacent to the ligand domain, and then at an upstream site (S2) within the prodomain. Cleavage at the second site regulates the stability of mature BMP4 and this in turn influences...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2937082/ https://ncbi.nlm.nih.gov/pubmed/20659445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.07.019 |
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