The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor

Proteolytic maturation of proBMP-4 is required to generate an active signaling molecule. We show that proBMP-4 is cleaved by furin in a sequential manner. Cleavage at a consensus furin site adjacent to the mature ligand domain allows for subsequent cleavage at an upstream nonconsensus furin site wit...

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Bibliografiset tiedot
Päätekijät: Cui, Yanzhen, Hackenmiller, Renee, Berg, Linnea, Jean, François, Nakayama, Takuya, Thomas, Gary, Christian, Jan L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2001
Aiheet:
Research Communication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC312809/
https://ncbi.nlm.nih.gov/pubmed/11691831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.940001
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