The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor

Proteolytic maturation of proBMP-4 is required to generate an active signaling molecule. We show that proBMP-4 is cleaved by furin in a sequential manner. Cleavage at a consensus furin site adjacent to the mature ligand domain allows for subsequent cleavage at an upstream nonconsensus furin site wit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Cui, Yanzhen, Hackenmiller, Renee, Berg, Linnea, Jean, François, Nakayama, Takuya, Thomas, Gary, Christian, Jan L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2001
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC312809/
https://ncbi.nlm.nih.gov/pubmed/11691831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.940001
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados