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Site-specific Cleavage of BMP4 by Furin, PC6, and PC7

Bone morphogenetic proteins (BMPs) require proteolytic activation by members of the proprotein convertase (PC) family. Pro-BMP4 is initially cleaved at a site adjacent to the mature ligand domain (S1) and then at an upstream site (S2) within the prodomain. Cleavage at the S2 site, which appears to o...

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Detalhes bibliográficos
Main Authors: Nelsen, Sylvia M., Christian, Jan L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785643/
https://ncbi.nlm.nih.gov/pubmed/19651771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028506
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