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Site-specific Cleavage of BMP4 by Furin, PC6, and PC7
Bone morphogenetic proteins (BMPs) require proteolytic activation by members of the proprotein convertase (PC) family. Pro-BMP4 is initially cleaved at a site adjacent to the mature ligand domain (S1) and then at an upstream site (S2) within the prodomain. Cleavage at the S2 site, which appears to o...
Guardat en:
| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785643/ https://ncbi.nlm.nih.gov/pubmed/19651771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028506 |
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