TLR4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3(+) T(regs) during intestinal inflammation

T(regs) play a crucial role in the maintenance of intestinal immune homeostasis. However, significant numbers of Foxp3(+) T(regs) accumulate in the inflamed lesions in experimental colitis and in IBD patients. T(reg) production of the proinflammatory cytokines IFN-γ and/or IL-17 may arguably explain...

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Autores principales: Cao, Anthony T., Yao, Suxia, Stefka, Andrew T., Liu, Zhanju, Qin, Hongwei, Liu, Houpu, Evans-Marin, Heather L., Elson, Charles O., Nagler, Cathryn R., Cong, Yingzi
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Leukocyte Biology 2014
Materias:
Inflammation, Extracellular Mediators, & Effector Molecules
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197555/
https://ncbi.nlm.nih.gov/pubmed/25015957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0114-056RR
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