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In vitro Differentiation of Thymic T(reg )Cell Progenitors to Mature Thymic T(reg )Cells

Thymic T(reg) cell differentiation occurs via a two-step process. Step one generates T(reg) cell progenitors (T(reg)P) and is driven by strong TCR interactions with antigens presented in the thymus. Step two is initiated by activation of STAT5 via IL-2, or IL-15, leading to mature T(reg) cells capab...

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Dades bibliogràfiques
Publicat a:Bio Protoc
Autors principals: Owen, David L., Farrar, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: Bio-Protocol 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854127/
https://ncbi.nlm.nih.gov/pubmed/33654840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.3335
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