Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy

The KCC2 cotransporter establishes the low neuronal Cl(−) levels required for GABA(A) and glycine (Gly) receptor-mediated inhibition, and KCC2 deficiency in model organisms results in network hyperexcitability. However, no mutations in KCC2 have been documented in human disease. Here, we report two...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Kahle, Kristopher T, Merner, Nancy D, Friedel, Perrine, Silayeva, Liliya, Liang, Bo, Khanna, Arjun, Shang, Yuze, Lachance-Touchette, Pamela, Bourassa, Cynthia, Levert, Annie, Dion, Patrick A, Walcott, Brian, Spiegelman, Dan, Dionne-Laporte, Alexandre, Hodgkinson, Alan, Awadalla, Philip, Nikbakht, Hamid, Majewski, Jacek, Cossette, Patrick, Deeb, Tarek Z, Moss, Stephen J, Medina, Igor, Rouleau, Guy A
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196980/
https://ncbi.nlm.nih.gov/pubmed/24928908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438840
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares