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Therapeutic antisense oligonucleotides against cancer: hurdling to the clinic

Under clinical development since the early 90's and with two successfully approved drugs (Fomivirsen and Mipomersen), oligonucleotide-based therapeutics has not yet delivered a clinical drug to the market in the cancer field. Whilst many pre-clinical data has been generated, a lack of understan...

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Détails bibliographiques
Auteurs principaux: Moreno, Pedro M. D., Pêgo, Ana P.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196572/
https://ncbi.nlm.nih.gov/pubmed/25353019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2014.00087
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