Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats

BACKGROUNDS & AIMS: We studied the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) as a possible therapy for non-steroidal anti-inflammatory drug (NSAID)-induced intestinal ulcers. Luminal nutrients release endogenous GLP-2 from enteroendocrine L cells. Since GLP-2 is degraded by dipept...

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Detalhes bibliográficos
Main Authors: Inoue, Takuya, Higashiyama, Masaaki, Kaji, Izumi, Rudenkyy, Sergiy, Higuchi, Kazuhide, Guth, Paul H., Engel, Eli, Kaunitz, Jonathan D, Akiba, Yasutada
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196264/
https://ncbi.nlm.nih.gov/pubmed/24379150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-013-3001-6
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