Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum

Intestinal endocrine cells release gut hormones, including glucagon-like peptides (GLPs), in response to luminal nutrients. Luminal l-glutamate (l-Glu) and 5′-inosine monophosphate (IMP) synergistically increases duodenal HCO(3)(−) secretion via GLP-2 release. Since L cells express the bile acid rec...

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Main Authors: Inoue, Takuya, Wang, Joon-Ho, Higashiyama, Masaaki, Rudenkyy, Sergiy, Higuchi, Kazuhide, Guth, Paul H., Engel, Eli, Kaunitz, Jonathan D., Akiba, Yasutada
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
Fag:
Mucosal Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469594/
https://ncbi.nlm.nih.gov/pubmed/22821947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00195.2012
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