Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum

Regulation of localized extracellular pH (pH(o)) maintains normal organ function. An alkaline microclimate overlying the duodenal enterocyte brush border protects the mucosa from luminal acid. We hypothesized that intestinal alkaline phosphatase (IAP) regulates pH(o) due to pH-sensitive ATP hydrolys...

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Main Authors: Mizumori, Misa, Ham, Maggie, Guth, Paul H, Engel, Eli, Kaunitz, Jonathan D, Akiba, Yasutada
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2009
Fag:
Alimentary
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742288/
https://ncbi.nlm.nih.gov/pubmed/19451200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.172270
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