Endogenous Luminal Surface Adenosine Signaling Regulates Duodenal Bicarbonate Secretion in Rats

Luminal ATP increases duodenal bicarbonate secretion (DBS) via brush border P2Y receptors. Because ATP is sequentially dephosphorylated to adenosine (ADO) and the brush border highly expresses adenosine deaminase (ADA), we hypothesized that luminal [ADO] regulators and sensors, including P1 receptor...

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Autors principals: Ham, Maggie, Mizumori, Misa, Watanabe, Chikako, Wang, Joon-Ho, Inoue, Takuya, Nakano, Takanari, Guth, Paul H., Engel, Eli, Kaunitz, Jonathan D., Akiba, Yasutada
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2010
Matèries:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993549/
https://ncbi.nlm.nih.gov/pubmed/20805305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.171520
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