Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum

Regulation of localized extracellular pH (pH(o)) maintains normal organ function. An alkaline microclimate overlying the duodenal enterocyte brush border protects the mucosa from luminal acid. We hypothesized that intestinal alkaline phosphatase (IAP) regulates pH(o) due to pH-sensitive ATP hydrolys...

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Bibliographic Details
Main Authors: Mizumori, Misa, Ham, Maggie, Guth, Paul H, Engel, Eli, Kaunitz, Jonathan D, Akiba, Yasutada
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2009
Subjects:
Alimentary
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742288/
https://ncbi.nlm.nih.gov/pubmed/19451200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.172270
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