Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration

The gut incretin glucagon-like peptide-1 (GLP-1) and the intestinotropic hormone GLP-2 are released from enteroendocrine L cells in response to ingested nutrients. Treatment with an exogenous GLP-2 analogue increases intestinal villous mass and prevents intestinal injury. Since GLP-2 is rapidly degr...

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Pubblicato in:J Clin Biochem Nutr
Autori principali: Fujiwara, Kaori, Inoue, Takuya, Yorifuji, Naoki, Iguchi, Munetaka, Sakanaka, Taisuke, Narabayashi, Ken, Kakimoto, Kazuki, Nouda, Sadaharu, Okada, Toshihiko, Ishida, Kumi, Abe, Yosuke, Masuda, Daisuke, Takeuchi, Toshihisa, Fukunishi, Shinya, Umegaki, Eiji, Akiba, Yasutada, Kaunitz, Jonathan D., Higuchi, Kazuhide
Natura: Artigo
Lingua:Inglês
Pubblicazione: the Society for Free Radical Research Japan 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345177/
https://ncbi.nlm.nih.gov/pubmed/25759522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3164/jcbn.14-111
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