Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation

Intracellular killing of Streptococcus pneumoniae is complemented by induction of macrophage apoptosis. Here, we show that the toxin pneumolysin (PLY) contributes both to lysosomal/phagolysosomal membrane permeabilization (LMP), an upstream event programing susceptibility to apoptosis, and to apopto...

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Bibliografski detalji
Glavni autori: Bewley, Martin A., Naughton, Michael, Preston, Julie, Mitchell, Andrea, Holmes, Ashleigh, Marriott, Helen M., Read, Robert C., Mitchell, Timothy J., Whyte, Moira K. B., Dockrell, David H.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Microbiology 2014
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196231/
https://ncbi.nlm.nih.gov/pubmed/25293758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01710-14
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