Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation

Intracellular killing of Streptococcus pneumoniae is complemented by induction of macrophage apoptosis. Here, we show that the toxin pneumolysin (PLY) contributes both to lysosomal/phagolysosomal membrane permeabilization (LMP), an upstream event programing susceptibility to apoptosis, and to apopto...

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Autors principals: Bewley, Martin A., Naughton, Michael, Preston, Julie, Mitchell, Andrea, Holmes, Ashleigh, Marriott, Helen M., Read, Robert C., Mitchell, Timothy J., Whyte, Moira K. B., Dockrell, David H.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Microbiology 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196231/
https://ncbi.nlm.nih.gov/pubmed/25293758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01710-14
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