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Reversal of cystic fibrosis phenotype in a cultured Δ508 cystic fibrosis transmembrane conductance regulator cell line by oligonucleotide insertion

Cystic fibrosis (CF) is a lethal genetic disorder that is due to mutations in the gene encoding the cAMP-activated anion CF transmembrane conductance regulator (CFTR) channel. A three-nucleotide base deletion (TTT), encoding phenylalanine in position 508 of the translatable CFTR sequence (accompanie...

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Bibliografische gegevens
Hoofdauteurs: Zamecnik, Paul C., Raychowdhury, Malay K., Tabatadze, David R., Cantiello, Horacio F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2004
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC419572/
https://ncbi.nlm.nih.gov/pubmed/15148387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401933101
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