Leptin modulates β cell expression of IL-1 receptor antagonist and release of IL-1β in human islets

High concentrations of glucose induce β cell production of IL-1β, leading to impaired β cell function and apoptosis in human pancreatic islets. IL-1 receptor antagonist (IL-1Ra) is a naturally occurring antagonist of IL-1β and protects cultured human islets from glucotoxicity. Therefore, the balance...

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Autors principals: Maedler, Kathrin, Sergeev, Pavel, Ehses, Jan A., Mathe, Zoltan, Bosco, Domenico, Berney, Thierry, Dayer, Jean-Michel, Reinecke, Manfred, Halban, Philippe A., Donath, Marc Y.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC419570/
https://ncbi.nlm.nih.gov/pubmed/15141093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305683101
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