Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

Context: Elevated glucose levels impair islet function and survival, and it has been proposed that intraislet expression of IL-1β contributes to glucotoxicity. Objective: The objective was to investigate IL-1β mRNA expression in near-pure β-cells of patients with type 2 diabetes (T2DM) and study the...

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Autori principali: Böni-Schnetzler, Marianne, Thorne, Jeffrey, Parnaud, Géraldine, Marselli, Lorella, Ehses, Jan A., Kerr-Conte, Julie, Pattou, Francois, Halban, Philippe A., Weir, Gordon C., Donath, Marc Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Endocrine Society 2008
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579638/
https://ncbi.nlm.nih.gov/pubmed/18664535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2008-0396
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