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Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to pancreatic β cells, causing impaired insulin secretion. IL-1β is a proinflammatory cytokine acting during the autoimmune process of type 1 diabetes. IL-1β inhibits β cell function and promotes Fas-triggered apoptosis in part...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2002
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151125/ https://ncbi.nlm.nih.gov/pubmed/12235117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15318 |
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