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Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to pancreatic β cells, causing impaired insulin secretion. IL-1β is a proinflammatory cytokine acting during the autoimmune process of type 1 diabetes. IL-1β inhibits β cell function and promotes Fas-triggered apoptosis in part...

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Udgivet i:J Clin Invest
Principais autores: Maedler, Kathrin, Sergeev, Pavel, Ris, Frédéric, Oberholzer, José, Joller-Jemelka, Helen I., Spinas, Giatgen A., Kaiser, Nurit, Halban, Philippe A., Donath, Marc Y.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151125/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12235117/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI15318
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