FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication

Type 2 diabetes mellitus results from an inadequate adaptation of the functional pancreatic β cell mass in the face of insulin resistance. Changes in the concentration of glucose play an essential role in the regulation of β cell turnover. In human islets, elevated glucose concentrations impair β ce...

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Bibliographic Details
Main Authors: Maedler, Kathrin, Fontana, Adriano, Ris, Frédéric, Sergeev, Pavel, Toso, Christian, Oberholzer, José, Lehmann, Roger, Bachmann, Felix, Tasinato, Andrea, Spinas, Giatgen A., Halban, Philippe A., Donath, Marc Y.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC123051/
https://ncbi.nlm.nih.gov/pubmed/12060768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122686299
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