The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells

OCH, a sphingosine-truncated analog of α-galactosylceramide (αGC), is a potential therapeutic reagent for a variety of Th1-mediated autoimmune diseases through its selective induction of Th2 cytokines from natural killer T (NKT) cells. We demonstrate here that the NKT cell production of IFN-γ is mor...

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Bibliographic Details
Main Authors: Oki, Shinji, Chiba, Asako, Yamamura, Takashi, Miyake, Sachiko
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC419488/
https://ncbi.nlm.nih.gov/pubmed/15173890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420862
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