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Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) mediated by Th17 and Th1 cells. DNA microarray analysis previously showed that NR4A2, an orphan nuclear receptor, is strongly up-regulated in the peripheral blood T cells of MS. Here, we report that NR4A2 plays a pi...

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Hlavní autoři: Doi, Yoshimitsu, Oki, Shinji, Ozawa, Tomoko, Hohjoh, Hirohiko, Miyake, Sachiko, Yamamura, Takashi
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426110/
https://ncbi.nlm.nih.gov/pubmed/18550828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803454105
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