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Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) mediated by Th17 and Th1 cells. DNA microarray analysis previously showed that NR4A2, an orphan nuclear receptor, is strongly up-regulated in the peripheral blood T cells of MS. Here, we report that NR4A2 plays a pi...

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Autores principales: Doi, Yoshimitsu, Oki, Shinji, Ozawa, Tomoko, Hohjoh, Hirohiko, Miyake, Sachiko, Yamamura, Takashi
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426110/
https://ncbi.nlm.nih.gov/pubmed/18550828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803454105
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