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Chromatin regulates DNA torsional energy via topoisomerase II-mediated relaxation of positive supercoils
Eukaryotic topoisomerases I (topo I) and II (topo II) relax the positive (+) and negative (−) DNA torsional stress (TS) generated ahead and behind the transcription machinery. It is unknown how this DNA relaxation activity is regulated and whether (+) and (−)TS are reduced at similar rates. Here, we...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BlackWell Publishing Ltd
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4194091/ https://ncbi.nlm.nih.gov/pubmed/24859967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488091 |
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