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Topoisomerase II minimizes DNA entanglements by proofreading DNA topology after DNA strand passage
By transporting one DNA double helix (T-segment) through a double-strand break in another (G-segment), topoisomerase II reduces fractions of DNA catenanes, knots and supercoils to below equilibrium values. How DNA segments are selected to simplify the equilibrium DNA topology is enigmatic, and the b...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919613/ https://ncbi.nlm.nih.gov/pubmed/24185700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1037 |
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