Topoisomerase II minimizes DNA entanglements by proofreading DNA topology after DNA strand passage

By transporting one DNA double helix (T-segment) through a double-strand break in another (G-segment), topoisomerase II reduces fractions of DNA catenanes, knots and supercoils to below equilibrium values. How DNA segments are selected to simplify the equilibrium DNA topology is enigmatic, and the b...

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Bibliografiska uppgifter
Huvudupphovsmän: Martínez-García, Belén, Fernández, Xavier, Díaz-Ingelmo, Ofelia, Rodríguez-Campos, Antonio, Manichanh, Chaysavanh, Roca, Joaquim
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
Ämnen:
Nucleic Acid Enzymes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919613/
https://ncbi.nlm.nih.gov/pubmed/24185700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1037
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