Transcriptional supercoiling boosts topoisomerase II-mediated knotting of intracellular DNA

Recent studies have revealed that the DNA cross-inversion mechanism of topoisomerase II (topo II) not only removes DNA supercoils and DNA replication intertwines, but also produces small amounts of DNA knots within the clusters of nucleosomes that conform to eukaryotic chromatin. Here, we examine ho...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Valdés, Antonio, Coronel, Lucia, Martínez-García, Belén, Segura, Joana, Dyson, Sílvia, Díaz-Ingelmo, Ofelia, Micheletti, Cristian, Roca, Joaquim
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Nucleic Acid Enzymes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6649788/
https://ncbi.nlm.nih.gov/pubmed/31165864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz491
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