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Transcriptional supercoiling boosts topoisomerase II-mediated knotting of intracellular DNA
Recent studies have revealed that the DNA cross-inversion mechanism of topoisomerase II (topo II) not only removes DNA supercoils and DNA replication intertwines, but also produces small amounts of DNA knots within the clusters of nucleosomes that conform to eukaryotic chromatin. Here, we examine ho...
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6649788/ https://ncbi.nlm.nih.gov/pubmed/31165864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz491 |
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