Transcriptional supercoiling boosts topoisomerase II-mediated knotting of intracellular DNA

Recent studies have revealed that the DNA cross-inversion mechanism of topoisomerase II (topo II) not only removes DNA supercoils and DNA replication intertwines, but also produces small amounts of DNA knots within the clusters of nucleosomes that conform to eukaryotic chromatin. Here, we examine ho...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Valdés, Antonio, Coronel, Lucia, Martínez-García, Belén, Segura, Joana, Dyson, Sílvia, Díaz-Ingelmo, Ofelia, Micheletti, Cristian, Roca, Joaquim
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6649788/
https://ncbi.nlm.nih.gov/pubmed/31165864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz491
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