Transcriptional supercoiling boosts topoisomerase II-mediated knotting of intracellular DNA

Recent studies have revealed that the DNA cross-inversion mechanism of topoisomerase II (topo II) not only removes DNA supercoils and DNA replication intertwines, but also produces small amounts of DNA knots within the clusters of nucleosomes that conform to eukaryotic chromatin. Here, we examine ho...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Valdés, Antonio, Coronel, Lucia, Martínez-García, Belén, Segura, Joana, Dyson, Sílvia, Díaz-Ingelmo, Ofelia, Micheletti, Cristian, Roca, Joaquim
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6649788/
https://ncbi.nlm.nih.gov/pubmed/31165864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz491
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