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Topoisomerase II, not topoisomerase I, is the proficient relaxase of nucleosomal DNA
Eukaryotic topoisomerases I and II efficiently remove helical tension in naked DNA molecules. However, this activity has not been examined in nucleosomal DNA, their natural substrate. Here, we obtained yeast minichromosomes holding DNA under (+) helical tension, and incubated them with topoisomerase...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1478187/ https://ncbi.nlm.nih.gov/pubmed/16710299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601142 |
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